Pyogenic granuloma of the tongue early after allogeneic bone marrow transplantation for multiple myeloma

Oral complications occur frequently after bone marrow transplantation (BMT) . Some of them are caused by regimen-related toxicity of the preparative re gimen, and others by infections. In addition, oral tissues are targets of g raft-versus-host disease (GVHD). Oral granulomatous lesions are not a commo n complication after BMT, and are especially rare on the tongue. Such rare lesions reported in the literature, developed late after BMT with oral chro nic GVHD. We present here a patient who developed pyogenic granuloma of the tongue early after allogeneic BMT done for multiple myeloma. Regimen-relat ed mucositis, oral acute GVHD, the administration of cyclosporine A, and th e preexisting macroglossia might be responsible for the formation of granul oma.