Central role of PPAR alpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators

Authors
Corton, JC Lapinskas, PJ Gonzalez, FJ
Citation
Jc. Corton et al., Central role of PPAR alpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators, MUT RES-F M, 448(2), 2000, pp. 139-151
Citations number
90
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
ISSN journal
13861964 → ACNP
Volume
448
Issue
2
Year of publication
2000
Pages
139 - 151
Database
ISI
SICI code
1386-1964(20000317)448:2<139:CROPAI>2.0.ZU;2-1
Abstract
Peroxisome proliferators (PP) are a large class of structurally dissimilar chemicals. These chemicals have diverse effects in rodents and humans, incl uding regulation of lipid metabolism, growth promotion, and induction of he patocarcinogenesis. Most, if not all, effects of PP are mediated by three m embers of the nuclear receptor superfamily called PP-activated receptors (P PAR). In this review, we discuss the evidence that PPAR alpha, the predomin ant PPAR in the, liver is involved in the growth promoting and hepatocarcin ogenic effects of PP. (C) 2000 Elsevier Science B.V. All rights reserved.