Restoration of impaired T-cell proliferation after parathyroidectomy in hemodialysis patients

Background/Aims: Severe secondary hyperparathyroidism is not infrequent in hemodialysis patients and recent studies suggest that parathyroid hormone ( PTH) may play a role in the genesis of cell immunity abnormalities in uremi a, The aim of the present study is to describe the effect of parathyroidect omy on T- and B-cell functions in hemodialysis patients, Methods: The study was performed on 6 patients with severe secondary hyperparathyroidism. iPT H, B, CD4(+), CD8(+), total number of lymphocytes, lymphoproliferative resp onse to PHA, PWM and Candidin, and IgG, IgM, IL-2 production in vitro were determined 1 day before and 4 months after parathyroidectomy, Results: The lymphoproliferative response to PHA increased significantly after parathyro idectomy, We also observed a trend to an increase in production of IgG and IgM after PWM stimulation before therapy, Conclusion: The present study sug gests that patients with extremely high levels of PTH show a complete resto ration of impaired T-cell proliferation after parathyroidectomy, Copyright (C) 2000 S. Karger AG, Basel.