In-line proximity effects in extended 7-azanorbornanes. 1. A new concept for modifying effector group separation based on the control of N-invertomergeometry

Control of N-substituent geometry in fused 7-azanorbornane systems is based on the dominance of one proximate bridge (sentinel X) over the other (sent inel Y) relative to the N-bridge; the N-inversion equilibrium can effective ly be displaced in favor of a single invertomer, This study has used a comb ination of synthesis, crystallography, and molecular modeling to establish stereostructures.