Addition of metallo enolates to chiral 1-acylpyridinium salts: Total synthesis of (+)-cannabisativine

Authors
Kuethe, JT Comins, DL
Citation
Jt. Kuethe et Dl. Comins, Addition of metallo enolates to chiral 1-acylpyridinium salts: Total synthesis of (+)-cannabisativine, ORG LETT, 2(6), 2000, pp. 855-857
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
6
Year of publication
2000
Pages
855 - 857
Database
ISI
SICI code
1523-7060(20000323)2:6<855:AOMETC>2.0.ZU;2-V
Abstract
A novel route to the first asymmetric synthesis of (+)-cannabisativine (1) is described. The total synthesis of 1 was accomplished with a high degree of regio- and stereoselectivity in 19 steps and 9% overall yield.