Selective formation of pyrrola[3,2-d]pyrimidines from methyl[(N-benzoyl-S-methylisoihiocarbamoyl)amino]-1H-pyrrole-2-carboxylate

Authors
Pathak, VP
Citation
Vp. Pathak, Selective formation of pyrrola[3,2-d]pyrimidines from methyl[(N-benzoyl-S-methylisoihiocarbamoyl)amino]-1H-pyrrole-2-carboxylate, ORG PROC R, 4(2), 2000, pp. 129-130
Citations number
6
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC PROCESS RESEARCH & DEVELOPMENT
ISSN journal
10836160 → ACNP
Volume
4
Issue
2
Year of publication
2000
Pages
129 - 130
Database
ISI
SICI code
1083-6160(200003/04)4:2<129:SFOPFM>2.0.ZU;2-J
Abstract
A selective conversion of methyl 3-{[(benzoylamino)(methylsulfanyl)methylid ene]amino}-4-(3-pyridinylmethyl)-1H-pyrrole-2-carboxylate (1a) to 2-amino-7 -(3-pyridinylmethyl)-3,5-dihydro-4H-pyrrolo [3,2-d]pyrimidine-4-one (2a) in methanolic ammonia in the presence of sodium amide is described.