The regulatory role of MRP8 (S100A8) and MRP14 (S100A9) in the transendothelial migration of human leukocytes

Authors
Kerkhoff, C Eue, I Sorg, C
Citation
C. Kerkhoff et al., The regulatory role of MRP8 (S100A8) and MRP14 (S100A9) in the transendothelial migration of human leukocytes, PATHOBIOLOG, 67(5-6), 1999, pp. 230-232
Citations number
12
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
PATHOBIOLOGY
ISSN journal
10152008 → ACNP
Volume
67
Issue
5-6
Year of publication
1999
Pages
230 - 232
Database
ISI
SICI code
1015-2008(1999)67:5-6<230:TRROM(>2.0.ZU;2-V
Abstract
The hallmark of developing inflammatory lesions is the excess migration of recruited phagocytes together with the enhanced cell surface expression of adhesion molecules. Recent investigations give evidence that the two myeloi d-related proteins MRP8 (S100A8) and MRP14 (S100A9), which are abundant in activated or recruited phagocytes, may have a modulatory role in inflammato ry responses. S100A9 displays a regulatory role in the transendothelial mig ration of human monocytes, and the secreted S100A8/A9 complex may serve as a transport protein to move arachidonic acid to its target cells. Copyright (C) 2000 S. Karger AG, Basel.