Anemia secondary to mycophenolate mofetil (MMF) was recently described in e
xperimental animals. A clinical association between MMF and anemia has been
observed, but there are no proven reports. We describe a girl with chronic
graft failure who developed erythroid aplasia under immunosuppression with
MMF. She showed prompt resolution when MMF was discontinued and a recurren
ce of this clinical course when MMF was restarted. As re-challenge with a m
edication is the most definitive approach for showing a direct relationship
between the drug and the side effect, this case clearly demonstrates that
MMF can cause erythroid aplasia.