Multiple myeloma of the IgA-type with biclonal gammopathy and disorder of primary haemostasis in a German shepherd dog

This case report describes a ten-year-old German shepherd dog suffering fro m a multiple myeloma. This was diagnosed by means of biclonal gammopathy, r adiographically identified multiple osteolytic lesions of both scapulae, di stinct plasma cell infiltration of the bone marrow as well as relatively la rge amounts of immunoglobulin light chains in the urine. Gel electrophoreti c and immunoblot analyses of the serum indicated predominance of immunoglob ulin A. Laboratory findings revealed a complex disorder of haemostasis. Thi s included the decrease of the activity of numerous coagulation factors, ab ove all, of factors VII (25 %), XI (39 %), and XIII (36 %), of plasminogen, different inhibitors, and the primary haemostasis as well. Platelet functi on disorder was indicated by a prolonged capillary bleeding time exceeding the reference values twofold despite normal platelet count. Additionally, r educed platelet aggregation was found using different inductors. Initiated chemotherapy was stopped by the owner. Euthanasia occurred a few days later .