Genetic amniocentesis in women 20-34 years old: associated risks

The aim of this retrospective controlled study is to evaluate the impact of predisposing factors on amniocentesis-related fetal loss. It comprises 391 0 consecutive cases of women, aged 20-34 years, who had genetic amniocentes is during the years 1992-97 (study group). The control group comprised 5324 women under 35, at low risk for Down syndrome, during the same period. The fetal losses in both groups were analysed, in respect of: (a) maternal his torical conditions; and/or (b) bleeding during current pregnancy. The leadi ng indication for amniocentesis in women 20-34 years was maternal anxiety, mainly for marginal age (33-34 years), which accounted for a remarkable 34. 4% of the study group. Total fetal loss rate up to the 28th week was 2.1% i n the study group versus 1.5% in controls. A history of previous spontaneou s or induced abortions, as well as bleeding during the current pregnancy, w as associated with a substantial rise of fetal loss in both groups. In case s with no predisposing factors, the added fetal loss rate was 0.03%. previo us abortions and bleeding during the current pregnancy are associated with the most fetal losses after amniocentesis. In the absence of these, the add ed fetal loss rate (0.03%) is non-significant. Copyright (C) 2000 John Wile y & Sons, Ltd.