K. Sundfor et al., Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: relationships to pretreatment tumor oxygenation and vascularization, RADIOTH ONC, 54(2), 2000, pp. 101-107
Citations number
29
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Poor outcome of treatment was found to be associated with low oxygen tensio
n in the primary tumor and not with high intratumor microvessel density in
40 patients with advanced squamous cell carcinoma of the uterine cervix. Mu
ltivariate Cox regression analysis identified the total volume of the hypox
ic tumor regions, i.e. the tumor subvolume having pO(2) values below 5 mmHg
, as a significant prognostic factor for locoregional control, disease-free
survival, and overall survival. Other important prognostic factors, identi
fied by univariate Cox regression analysis, were tumor volume, the fraction
of pO(2) readings giving pO(2) values below 5 mmHg, and tumor stage. (C) 2
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