Reaction of pyrimidyl esters of some phosphorus acids with isomeric butyl alcohols

A series of pyrimidyl esters of some phosphorus acids was prepared with the purpose of investigation of their reaction with isomeric butyl alcohols. A ccording to P-31 NMR data, the obtained phosphates all are capable of phosp horylating isomeric butyl alcohols. The reactions with diphenyl (4-oxo-3,4- dihydro-2-pyrimidyl) phosphate and diphenyl (2- pyrimidyl) phosphate occur in quantitative yield under mild conditions, and the reactions with dipheny l (4,6-dimethyl-2-pyrimidyl) phosphate and dibutyl (4,6-dimethyl-2-pyrimidy l) phosphate require severe conditions to occur. In the latter two cases, c ertain reaction selectivity was observed, depending on the nature of the so lvent and some other factors. Pyrimidyl esters of sulfur-containing phospho rus acids do not react with isomeric butyl alcohols under the studied condi tions.