The success rate and complications from femoral arterial and venous ca
theterization in infants and children in a university affiliate pediat
ric intensive care unit were determined prospectively over a 2-year pe
riod. We also performed a meta-anal)Isis from published literature to
determine the combined estimates of noninfectious and infectious compl
ications (with 95% confidence limits) using the in verse variance-weig
hted method. Success rates were 94.5% and 94.4% for femoral arterial (
n = 110) and venous (n = 89) catheterizations, respectively, and were
related to operator expertise, age, and hemodynamic status, Median age
was 2.4 years and 1.1 year for arterial and venous catheterizations,
respectively. Immediate complications were hematoma (10.9% arterial, 1
6.8% venous) and minor bleeding (13.6% arterial, 13.5% venous). Decrea
sed pulses occurred with 7.7% of arterial catheterizations, and lower
limb swelling occurred in 9.5% of venous catheterizations. Vascular co
mplications occurred only in infants and resolved within 7-14 days. Ca
theter-related infections occurred in 1.9% of arterial and 3.6% of ven
ous catheterizations. The mean duration of catheterization was 5.3 day
s and 6.3 days with femoral arterial and venous catheterizations, resp
ectively. Meta-analysis of published studies shows that the estimates
for noninfectious complications were 5.0%, 10.1%, 1.1%, and 1.8% for f
emoral arterial, femoral venous, axillary arterial, and nonfemoral ven
ous catheters, respectively. The estimates for catheter-related infect
ion were 2.5%, 3.7%, and 3.0% for femoral arterial, femoral venous, an
d nonfemoral venous catheters, respectively. The meta-analytic estimat
es for complication rates from published literature are not significan
tly different from the rates observed in our study. Femoral arterial a
nd venous catheterization in infants and children are safe with an exp
ected high success rate and acceptably low complication rates.