Representative samples of female (N = 119) and male (N = 100) guests were s
elected at two inner city soup kitchens. In the preceding month, 75% used c
ocaine/crack and 25% used heroin/opiates as determined by hair analysis. Re
latively few guests (25%) were in substance dependency treatment. Infectiou
s disease rates were: HIV (16%), hepatitis B exposure (21%), hepatitis B ca
rrier (6%), syphilis exposure (15%). Years of injecting drug use and homele
ssness/marginal housing were associated with HIV infection and hepatitis B
exposure. Soup kitchens should be prime locations for outreach to cocaine/c
rack and heroin users in need of treatment, medical care, and interventions
to prevent infectious disease transmission.