Iv. Kozlova et al., Apudocytes and mast cells in chronic inflammation of the colon: Clinicomorphological collerations, TERAPEVT AR, 72(2), 2000, pp. 32-35
Aim. To study functional morphology of a total population of endocrine cell
s of colon mucosa, mast and enterochromaffine cells.
Materials and methods. Light and electrone microscopy, immunohistochemical
methods, morphometry were used to study endocrine and mast cells of the sig
moid colon in inflammation.
Results. Changes of functional morphology and size of endocrine and mast ce
ll population as well as apudocytes producing serotonin, melatonin, vasoint
estinal peptides were stated. Apudocyte and mass cell functional morphology
, clinical symptoms and mucosal structural changes correlated Specificity o
f some parameters in Chron's disease is shown.
Conclusion. The results may provide additional criteria in diagnosis of dif
ferent variants of chronic colitis.