Main causes of hyperuricemia in diabetes mellitus

Aim. investigation of hyperuricemia (HU) causes in diabetes mellitus (DM). Materials and methods. Purin, lipid and carbohydrate metabolisms, renal exc retion of uric acid (UA) were examined in 535 patients with DM. Non-insulin -dependent DM (NIDDM) and insulin-dependent ent DM (IDDM) were diagnosed in 369 and 166 patients, respectively. Results. Hyperglycemia and glucosuria in DM enhance renal excretion of UA. However, HU in DM occurs significantly more frequently than in the populati on (22.5+/-3.0% in IDDM and 29.9+/-2.5% of cases in NIDDM). Conclusion. In NIDDM, HU genesis is strongly related with renal lesions. In IDDM, HU genesis is associated with metabolic factors (high activity of xa ntinoxidase, lipid peroxidation, obesity). However, combination of factors is, as a rule, involved in HU development: renal dysfunction and hyperprodu ction of UA.