Biosynthesis of myxothiazol Z, the ester-analog of myxothiazol A in Myxococcus fulvus

Authors
Steinmetz, H Forche, E Reichenbach, H Hofle, G
Citation
H. Steinmetz et al., Biosynthesis of myxothiazol Z, the ester-analog of myxothiazol A in Myxococcus fulvus, TETRAHEDRON, 56(12), 2000, pp. 1681-1684
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
12
Year of publication
2000
Pages
1681 - 1684
Database
ISI
SICI code
0040-4020(20000317)56:12<1681:BOMZTE>2.0.ZU;2-Z
Abstract
Among myxobacteria only strains of Myxococcus fulvus are able to produce in addition to the well known myxothiazol A (1) an analog, myxothiazol Z (2), with an ester-type beta-methoxyacrylate pharmacophore. Feeding experiments with labeled precursors established its biosynthesis from the amide (1) pr esumably via an O-methyl imidate (3). (C) 2000 Elsevier Science Ltd. All ri ghts reserved.