arabino-fluorooligonucleotide N3 '-> P5 ' phosphoramidates: synthesis and properties

Authors
Schultz, RG Gryaznov, SM
Citation
Rg. Schultz et Sm. Gryaznov, arabino-fluorooligonucleotide N3 '-> P5 ' phosphoramidates: synthesis and properties, TETRAHEDR L, 41(12), 2000, pp. 1895-1899
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
12
Year of publication
2000
Pages
1895 - 1899
Database
ISI
SICI code
0040-4039(20000318)41:12<1895:AN'P'P>2.0.ZU;2-Y
Abstract
Oligonucleotide analogues with a novel su,oar-phosphate backbone containing 2'-arabino-fluoronucleosides and phosphoramidate 3'-NHP(O)(O-)O-5' internu cleoside linkages were prepared. These compounds have demonstrated high bin ding affinity to complementary nucleic acids as well as greater acid stabil ity than the parent oligonucleotide N3' --> P5' phosphoramidates. (C) 2000 Elsevier Science Ltd. All rights reserved.