Let us assume that there is a monoecious random mating population that chan
ges cyclically in size. Then, the probability that a nonrecessive favorable
mutant is ultimately fixed, if it is originally present in a single hetero
zygote, is approximately proportional to the harmonic mean of the effective
population sizes in the cycle and inversely proportional to the population
size when the mutant appears, This approximation works well if the selecti
ve advantage s of the mutant is small and the length k of a cycle is small
in comparison with the population sizes in a cycle. If k is large the harmo
nic mean is, in general, replaced by a weighted harmonic mean that puts the
largest weights on reciprocals of effective population sizes in the first
few generations after the mutant appears, (C) 2000 Academic press.