Transcriptional repression by nuclear hormone receptors

Repression by nuclear receptor plays important roles in a cute promyelocyti c leukemia and other diseases. nuclear receptor corepressor (N-CoR) and SMR T (silencing mediator of retinoic acid and thyroid hormone receptor) are co repressor proteins whose modular structure facilitates receptor interaction as well as translation of repression signals involving histone deacetylati on, alterations in chromatin structure and direct interactions with the bas al transcription machinery. Interactions between nuclear receptors and core pressor complexes have multiple determinants. This allows regulation, and p otentially therapeutic manipulation, of receptor, corepressor, cell-type an d target-gene specificity.