c-myc Oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer

A pilot study on relationships of selected molecular factors (c-myc oncogen e average gene copy numbers (AGCN); serum CEA and CA 15.3 antigen levels; t umor cells' DNA values), to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viability che mosensitivity assay (ATP-CVA), was performed. Four drug combinations were t ested. A group of 75 cases of female primary breast cancer was assessed. Nu merous correlations were found among molecular factors tested but none, wit h the exception of tumor grading, of these reflected ex vivo chemosensitivi ty of tumors tested. The results suggest that the parameters tested may not be important factors related to adjuvant chemoresponsiveness of primary hu man breast cancer to tested drug combinations.