Genetic association study between alpha 1-antichymotrypsin polymorphism and Alzheimer disease in Chinese Han population

Authors
Tang, GM Jiang, SD Zhang, MY Lin, SC Qian, YP Wu, XD Wang, DX Jin, TG Gu, NF
Citation
Gm. Tang et al., Genetic association study between alpha 1-antichymotrypsin polymorphism and Alzheimer disease in Chinese Han population, AM J MED G, 96(2), 2000, pp. 133-135
Citations number
11
Categorie Soggetti
Molecular Biology & Genetics
Journal title
AMERICAN JOURNAL OF MEDICAL GENETICS
ISSN journal
01487299 → ACNP
Volume
96
Issue
2
Year of publication
2000
Pages
133 - 135
Database
ISI
SICI code
0148-7299(20000403)96:2<133:GASBA1>2.0.ZU;2-6
Abstract
We investigated a common signal peptide polymorphism in the or l-antichymot rypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 h ealthy control subjects in Chinese Dan population. We found no significant difference in the distribution of ACT polymorphism between AD cases and con trols, and failed to detect any effects of ACT genotypes associated with AD . Thus, our data do not support the involvement of ACT polymorphism in the risk of AD in Chinese Dan population. (C) 2000 Wiley-Liss, Inc.