Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia andschizoaffective disorder

A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting link age to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with sch izophrenia. Multipoint analyses failed to reveal evidence for linkage to an y portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emph asis to the inconsistency of the findings concerning linkage in schizophren ia. (C) 2000 Wiley-liss, Inc.