Al. Cubilla et al., Warty (condylomatous) squamous cell carcinoma of the penis - A report of 11 cases and proposed classification of 'verruciform' penile tumors, AM J SURG P, 24(4), 2000, pp. 505-512
Citations number
33
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Within the spectrum of penile squamous cell carcinomas, those that we descr
iptively refer to collectively as the "verruciform" lesions are particularl
y difficult to subclassify, In a review of 50 such tumors, we found 11 dist
inctive neoplasms with condylomatous features conforming to the appearance
of so-called "warty (condylomatous) carcinoma." The average patient age was
55 years and the average duration of disease was 19 months. The primary tu
mor involved multiple anatomic sites (glans, coronal sulcus, and foreskin)
in seven cases and a single site (glans or foreskin) in four cases. Grossly
, white to gray cauliflower-like tumors typically measuring approximately 5
cm were noted. Histologically the tumors were mainly papillomatous with ac
anthosis and hyperkeratosis. The papillae had prominent fibrovascular cores
. The most conspicuous microscopic findings were striking nuclear atypia of
koilocytotic type and clear cytoplasm. The interface between tumor and str
oma was irregular in the majority of cases; deep invasion df corpus caverno
sum was noted in five cases. The differential diagnosis included verrucous
carcinoma, low-grade papillary squamous cell carcinoma, not otherwise speci
fied, and giant condyloma acuminatum. Among other differences, the first tw
o lesions show no koilocytotic changes and the last lacks malignant feature
s and irregular stromal invasion. Metastatic spread occurred in two patient
s; both are alive with evidence of recurrent disease 12 and 72 months after
initial diagnosis. A third patient was alive with recurrent disease 12 mon
ths after diagnosis. Five patients were free of disease 8, 12, 24, 52, and
108 months after diagnosis. Three patients were lost to follow up. Warty (c
ondylomatous) carcinomas of the penis are morphologically distinctive verru
ciform neoplasms with features of human papillomavirus-related lesions and
should be distinguished from other verruciform tumors so that differences i
n behavior, if any, between these tumors will become established.