Insecticide resistance in insect vectors of human disease

Insecticide resistance is an increasing problem in many insect vectors of d isease. Our knowledge of the basic mechanisms underlying resistance to comm only used insecticides is well established. Molecular techniques have recen tly allowed us to start and dissect most of these mechanisms at the DNA lev el. The next major challenge will be to use this molecular understanding of resistance to develop novel strategies with which we can truly manage resi stance. State-of-the-art information on resistance in insect vectors of dis ease is reviewed in this context.