We discuss the time variation of the dust-to-gas mass ratio in spiral galax
ies, using the multiphase model of interstellar medium. The typical timesca
le of the phase change of an interstellar gas is similar to 10(7-8) yr in s
piral galaxies. Since the phase transition changes the filling factor of th
e cold gas where the dust growth occurs, the dust growth rate varies on tha
t timescale. In order to examine the response of the dust-to-gas ratio to t
he phase transition, we construct a model of the time evolution of the dust
-to-gas ratio. We adopt the three-phase model for the interstellar gas and
the Ikeuchi-Tomita model for the mass exchange between the phases. Accordin
g to the model, three types of solutions are possible: (1) all the gas is t
ransformed to a hot gas; (2) a stable stationary state of three phases is r
ealized; and (3) the filling factor of each phase cyclically changes. For t
he three types of solutions, the dust-to-gas ratio behaves as follows: for
solution 1, almost all the dust is destroyed (the dust-to-gas ratio becomes
similar to 0); for solution 2, the dust-to-gas ratio converges to a statio
nary state; and for solution 3, the dust-to-gas ratio varies cyclically In
response to the phase transition. In the case of solution 3, the amplitude
of the variation of the dust-to-gas ratio is large (nearly an order of magn
itude) if the dust growth timescale is shorter than the phase transition ti
mescale. This condition is easily satisfied in spiral galaxies. However, it
is difficult for dwarf galaxies to realize the condition, because their sm
all metallicity makes the dust growth timescale long.