Inflammation markers in the serum of salt miners

The inflammation markers alpha-1-antitrypsin (AAT), Clara cell protein (CC- 16), soluble interleukin-2-receptor (IL-R) and the soluble adhesion molecul e E-selectin, the intercellular adhesion molecule (ICAM-1) and the vascular adhesion molecule (VCAM-1) were determined in the serum of 195 salt-expose d miners to analyse dose-response relationships between markers and potash dust. Alpha-1-antitrypsin, Clara-cell protein, IL2-R, E-selectin and VCAM-1 were not changed by salt exposure, however the ICAM-1 level in the serum f ell slightly as the salt exposure increased. This effect was strongest in t he group of smokers, still visible in the group of ex-smokers, no effect wa s seen in nonsmokers. Markers, with the exception of VCAM-1, were influence d by tobacco exposure. Since markers were not elevated in relation to salt dust exposure, the results do not support an inflammatory effect of potash dust on the respiratory system.