Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA(4) and enzymatic conversion to the LTC4 analogue

Authors
Vidal, A Durand, T Vidal, JP Rossi, JC Ravasi, S Zarini, S Sala, A
Citation
A. Vidal et al., Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA(4) and enzymatic conversion to the LTC4 analogue, BIOORG MED, 10(7), 2000, pp. 665-668
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
7
Year of publication
2000
Pages
665 - 668
Database
ISI
SICI code
0960-894X(20000403)10:7<665:SO1AEC>2.0.ZU;2-7
Abstract
New photoaffinity probes based on C-19 position of leukotriene A(4) has bee n synthesized from 19-hydroxy-LTA(4) methyl eater. Enzymatic conversion int o the LTC4 analogue yielded a potential tool for the study of cys-LT2 recep tors. (C) 2000 Elsevier Science Ltd. All rights reserved.