Cortical bone loss contributes substantially to the degradation of skeletal
integrity associated with aging. However, animal models that closely mimic
age-related alterations in cortical bone are limited. The objective of thi
s study was to determine if aged rooster cortical bone demonstrates phenoty
pic alterations similar to those observed in aged human cortical bone (i.e,
, expansion of the endocortical and periosteal envelopes and elevated corti
cal porosity). When compared with young adult roosters, aged roosters demon
strated significant expansion of the endocortical (16%) and periosteal (10%
) envelopes, resulting in significantly increased cross-sectional moments o
f inertia. In addition, aged rooster bone demonstrated significantly elevat
ed cortical porosity (51%) and average area of porosity (83%). We conclude
that rooster bone demonstrates age-related adaptations similar to those of
humans at both tissue and cellular levels, and may therefore represent a re
latively useful, inexpensive animal model for investigating the mechanisms
of age-related bone loss. (Bone 26:361-365; 2000) (C) 2000 by Elsevier Scie
nce Inc. All rights reserved.