Neurocognitive correlates of stereotactic thalamotomy and thalamic stimulation in parkinsonian patients

In the present paper we have reviewed five different studies that relate to neuropsychological consequences of stereotactic thalamotomy and thalamic s timulation in patients with Parkinson's disease. The neuropsychological res ults are in a strict sense confined to thalamotomy and thalamic stimulation , although the more general message of the importance of investigating cogn itive functions before and after surgery applies to other stereotactic tech niques for surgical treatment of movement disorders as well. It is argued i n the paper that stereotactic thalamotomy provides a unique model for basic research on the neuropsychology of the thalamus, while in return, neuropsy chological tests for cognitive dysfunction after surgery may be the most im portant clinical follow-up. Three general conclusions seem warranted from t he data. (1) Parkinsonian patients are impaired on a range of cognitive fun ctions, including language processing, memory, and executive functions. (2) Stereotactic thalamotomy does not further impair the patient; instead, we observed improvement on some tests, particularly verbal memory. (3) In gene ral, there does not seem to be a laterality effect, depending on which side the thalamotomy lesion is applied. An exception to this are dichotically p resented simple speech sounds and autonomic responses. in both instances, l eft-sided brain stimulation produced enhanced performance, while lesioning the left thalamus impaired dichotic listening performance. Finally, we pres ent a new hypothesis for a mechanism behind the thalamotomy effect, based i n part on changes in arousal thresholds. (C) 2000 Academic Press.