Stereological studies have contributed with important results to the unders
tanding of brain abnormalities in schizophrenia. The data obtained from ste
reological studies of brains from schizophrenic patients, including studies
of the thalamus, hippocampus, and cortex, are discussed and suggest a cent
ral role of the thalamic nuclei in the etiology of the: disease. The basic
stereological tools are presented and possible biases in quantification stu
dies are discussed. (C) 2000 Elsevier Science B.V. All rights reserved.