Explaining the symptoms of schizophrenia: Abnormalities in the awareness of action

We propose that the primary cognitive deficit associated with delusions of control is a lack of awareness of certain aspects of motor control. This pr oblem arises because of a failure in the mechanism by which the predicted c onsequences of an action are derived from a forward model based on the inte nded sequence of motor commands, This problem leads to a number of behaviou ral consequences, such as a lack of central error correction, many of which have been observed in patients with delusions of control and related sympt oms, At the physiological level, delusions of control are associated with o ver-activity in parietal cortex. We suggest that this over-activity results from a failure to attenuate responses to sensations of limb movements even though these sensations can be anticipated on the basis of the movements i ntended. The lack of attenuation may arise from long range cortico-cortical disconnections which prevent inhibitory signals arising in the frontal are as which generate motor commands from reaching the appropriate sensory area s, (C) 2000 Elsevier Science B.V. All rights reserved.