Birth outcome following maternal use of metoclopramide

Aims Metoclopramide is an antiemetic drug used widely during pregnancy for nausea and vomiting. Because of its frequent use any adverse effects on inf ant health would have major public health implications. We therefore examin ed the safety of metoclopramide during pregnancy. Methods Using the Pharmaco-Epidemiological Prescription Database of North J utland County, we identified 309 women with singleton pregnancies who had p rescriptions for metoclopramide fom 1 January 1991 to 31 December 1996. Inf ormation on malformations, birth weight, preterm deliveries and stillbirth were compared with 13 327 references who did not receive prescriptions of a ny kind during pregnancy. Results Mean birth weight among exposed women was 3480 g compared with 3470 g among nonexposed. Based on logistic regression models no major differenc es in the risk were found concerning malformations (OR = 1.11; 95% confiden ce interval (CI): 0.6-2.1); low birth weight (OR = 1.79; 95% CI: 0.8-3.9) o r preterm delivery (OR = 1.02; 95 CI: 0.6-1.7). Conclusions We could not document any association between the use of metocl opramide during pregnancy and adverse pregnancy outcome. Because of the lim ited power of our study further research is required.