Trisomy of chromosome 10 in two cases of ovarian carcinoma

Simple numerical chromosome aberrations have been observed in tumorigenesis and may point to indicate initiating or early events in tumorigenesis. We have identified two cases of ovarian carcinomas with trisomy of chromosome 10 using conventional GTG-banding and fluorescence in situ hybridization, T his is, to our knowledge, the first report of trisomy 10 as a simple karyop tic abnormality observed in or arian carcinoma. These results suggest that further. studies investigating whether chromosome 10 genes are associated w ith thew pathogenesis of some or arian tumors are warranted. (C) Elsevier S cience, Inc., 2000. All rights reserved.