A novel t(11;12)(q23-24;q24) in a case of minimally-differentiated acute myeloid leukemia (AML-M0)

Authors
Cox, MC Scanzani, A Del Poeta, G Venditti, A Panetta, P Derme, V Sgro, R Masi, M Amadori, S
Citation
Mc. Cox et al., A novel t(11;12)(q23-24;q24) in a case of minimally-differentiated acute myeloid leukemia (AML-M0), CANC GENET, 118(1), 2000, pp. 76-79
Citations number
28
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
118
Issue
1
Year of publication
2000
Pages
76 - 79
Database
ISI
SICI code
0165-4608(20000401)118:1<76:ANTIAC>2.0.ZU;2-O
Abstract
Acute myeloid leukemia with minimal signs of myeloid differentiation (AML-M 0) is a recent addition to the FAB group classification. Chromosome data is scarce, but existing reports describe a high incidence of complex karyotyp es and myelodysplastic syndrome-like chromosome alterations, while single c hromosome translocations have rarely been reported. We describe the case of a co! ear-old woman diagnosed with AML-M0 with a nor el translocation t(11 ;12)(q23-24;q24) us the sole karyotypic marker. Fluorescence in situ hybrid ization analysis to assess MLL gene splitting did not show rearrangement of this oncogene. (C) Elsevier Science Inc., 2000. All rights reserved.