Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz

Authors
Markelz, AG Roitberg, A Heilweil, EJ
Citation
Ag. Markelz et al., Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz, CHEM P LETT, 320(1-2), 2000, pp. 42-48
Citations number
24
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
CHEMICAL PHYSICS LETTERS
ISSN journal
00092614 → ACNP
Volume
320
Issue
1-2
Year of publication
2000
Pages
42 - 48
Database
ISI
SICI code
0009-2614(20000331)320:1-2<42:PTSODB>2.0.ZU;2-3
Abstract
We report the first use of pulsed terahertz spectroscopy to examine low-fre quency collective vibrational modes of biomolecules. Broadband absorption i ncreasing with frequency was observed for lyophilized powder samples of cal f thymus DNA, bovine serum albumin and collagen in the 0.06-2.00 THz (2-67 cm(-1)) frequency range, suggesting that a large number of the low-frequenc y collective modes for these systems are IR active. Transmission measuremen ts at room temperature showed increasing FIR absorption with hydration and denaturing. (C) 2000 published by Elsevier Science B.V. All rights reserved .