Defibrotide in recurrent thrombotic thrombocytopenic purpura

Citation
Em. Pogliani et al., Defibrotide in recurrent thrombotic thrombocytopenic purpura, CL APPL T-H, 6(2), 2000, pp. 69-70
Citations number
12
Categorie Soggetti
Hematology
Journal title
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
ISSN journal
10760296 → ACNP
Volume
6
Issue
2
Year of publication
2000
Pages
69 - 70
Database
ISI
SICI code
1076-0296(200004)6:2<69:DIRTTP>2.0.ZU;2-K
Abstract
Thrombotic thrombocytopenic pul-pura (TTP) is a common illness characterize d by platelet thrombi within the microvascularization. In its natural cours e, this disease has had a mortality rate of 90%. Plasma infusion or exchang e achieved a survival rate of 70% to 90%. However, 10% to 30% of patients s urviving the initial TTP episode relapse at regular intervals. The treatmen t of recurrent forms of the disease remains a challenge; several approaches have been shown to induce medium to long term remissions. We describe a pa tient with recurrent TTP whose disease remitted after administration of def ibrotide.