Regulatory circuits in Caulobacter

The transcriptional regulator CtrA controls DNA replication, DNA methylatio n and cell division during the Caulobacter cell cycle. Recent work on this master cell cycle regulator has provided insight into its control mechanism s. Feedback regulation of ctrA transcription together with timed proteolysi s of CtrA determine the levels of the regulator during the cell cycle. Mult iple phosphorylation pathways regulate CtrA activity by a mechanism that in cludes dynamic subcellular localization of the corresponding sensor kinases .