Saturated saline enhances the effect of electrochemical therapy

We conducted this experiment to assess the effect of saline injection in el ectrochemical therapy. Platinum electrodes using direct current were insert ed into egg white or liver parenchyma. Pure water or 0.9%, 3%, or 26% sodiu m chloride were injected into various objects to compare with the control g roup (no injection). Power was set at 10 V. In the egg-white experiment, ga s bubbles and coagulated protein developed around the electrodes. In ex viv o liver, frothy reddish debris developed around the cathodes, while a harde ning and shrunken surface occurred around the anodes. The pH was 14 around the cathodes, 0 around the anodes. The electric current, the amount of coag ulated protein, and the severity of tissue damage were all in proportion to the concentrations of the injected saline. The volume destroyed in the 26% saline group was 8.1 times larger than that of the control group. Therefor e, injected saline, especially saturated saline, can enhance the effect of electrochemical therapy.