This paper, in the context of various cholera vaccine trials during the pre
sent century, examines critical issues of vaccine research, and demonstrate
s how the movement from laboratory to field, and then to routine practice i
nvolves the complex interaction between science, state and the public spher
e. Through narratives of scientists and administrators, the authors try to
show the social negotiations through which knowledge either moves from labo
ratory to the field or is. inhibited in this movement. Several. questions o
f scientific management, organisational structures and scientific diplomacy
are addressed, in addition to questions about notions of medical efficacy
and of risk and its perception by the! different Social actors.