Electrochemistry of anti-HIV agents

Authors
Lemoult, SC Cheng, Y Kontturi, K Schiffrin, DJ
Citation
Sc. Lemoult et al., Electrochemistry of anti-HIV agents, ELECTROCH C, 2(4), 2000, pp. 244-247
Citations number
14
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ELECTROCHEMISTRY COMMUNICATIONS
ISSN journal
13882481 → ACNP
Volume
2
Issue
4
Year of publication
2000
Pages
244 - 247
Database
ISI
SICI code
1388-2481(200004)2:4<244:EOAA>2.0.ZU;2-T
Abstract
Square wave voltammetry has been used to study the electrochemical behaviou r of anti-HIV drugs in aqueous solutions. The oxidation reaction of Carbovi r (1) at a Pt microelectrode occurs at 1.12 V versus SCE and the peak curre nt is proportional to the concentration. An electroanalytical technique for the determination of trace concentrations of Carbovir (1) is proposed and experimental conditions have been optimised. The effect of Cu(II) on the el ectrochemistry of nucleosides and nucleotides has also been studied. An equ ilibrium between the nucleotide-copper complex formed and the free nucleoti de is observed. (C) 2000 Elsevier Science S.A. All rights reserved.