Synthesis of various water-soluble C-60 derivatives and their superoxide-quenching activity

Authors
Okuda, K Hirota, T Hirobe, M Nagano, T Mochizuki, M Mashino, T
Citation
K. Okuda et al., Synthesis of various water-soluble C-60 derivatives and their superoxide-quenching activity, FUL SCI TEC, 8(1-2), 2000, pp. 89-104
Citations number
31
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
FULLERENE SCIENCE AND TECHNOLOGY
ISSN journal
1064122X → ACNP
Volume
8
Issue
1-2
Year of publication
2000
Pages
89 - 104
Database
ISI
SICI code
1064-122X(2000)8:1-2<89:SOVWCD>2.0.ZU;2-N
Abstract
In order to examine the utility of fullerene as a medicinal application, we evaluated the reaction between fullerene derivatives and active oxygen spe cies in vitro. This paper describes the synthesis of various water-soluble C-60 derivatives (cationic and anionic) and evaluation of their superoxide (O-2(-)) quenching activity. Cationic C-60 derivatives showed fairly high e fficiency.