Indocyanine green angiography in Sorsby's fundus dystrophy

Purpose: To report the indocyanine green angiographic findings in patients: with a fundus dystrophy characterized by subretinal deposits, macular atro phic or neovascular degeneration and peripheral chorioretinal atrophy which is most likely Sorsby's fundus dystrophy. Methods: A series of 11 clinically affected patients and 4 asymptomatic car riers, belonging to one autosomal dominant pedigree were examined with ster eoscopic funduscopy, fluorescein and indocyanine green angiography. Results: Subretinal deposits were found in 20 eyes of 10 patients. These de posits stained slightly on indocyanine green angiography, causing a reticul ar pattern. Two eyes had a disciform lesion and 3 geographic atrophy in the macula. A peripheral disciform lesion was found in 1 eye. Indocyanine gree n angiography identified peripapillary choroidal neovascularization in 2 ey es. Peripheral chorioretinal atrophy was found in 8 eyes of 4 patients, ass ociated with peripheral plaques that could only be identified by indocyanin e green angiography in 6 eyes of 3 patients. Conclusion: Indocyanine green angiography in Sorsby's fundus dystrophy may indicate the presence of homogeneously staining, well-demarcated peripheral areas of hyperfluorescence associated with chorioretinal atrophy. These pl aques correspond in our opinion to choroidal neovascularization which is ot herwise unsuspected.