High dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) in ovarian cancer

Ovarian cancer is a very chemosensitive tumor, but survival is poor due to the emergence of drag resistance. It may be possible to overcome resistance by using high dose chemotherapy supported by peripheral blood stem cell tr ansplantation. A review of retrospective studies of dose-intensity and phas e I/II high dose chemotherapy trials, and an analysis of the EBMT registry data is used as evidence to support the case for dose-intensification in ov arian cancer. As a result of this analysis there are now prospective random ized trials of high dose chemotherapy in ovarian cancer.