The case of a 26-year old woman with Chronic Fatigue Syndrome (CFS) is pres
ented. Multidimensional assessment showing severe debilitating fatigue and
considerable psychological, social and occupational impairment confirmed th
e diagnosis. Cognitive behavior therapy (CBT) was based on a tested causal
model of CFS and individual behavioral analyses. Rey elements in CBT were p
rocess variables from the CFS model, like sense of control, causal attribut
ions, physical activity and focusing on bodily functions. Goals were recove
ry from fatigue, returning to work and relapse prevention. The course of th
erapy is described in detail to illustrate difficulties in treating CFS. As
sessments were made five times, at baseline and at 8, 14, 21 and 33 months.
Comparison of the pretest, post-test and follow-up scores of the outcome v
ariables, fatigue and functional impairment and of the process variables sh
owed clinically significant improvement from the range of CFS patients to t
he range of healthy controls. (C) 2000 Elsevier Science Ltd. All rights res
erved.