R. Jorde et J. Sundsfjord, Bone mineral density and blood pressure in patients with asymptomatic hyperparathyroidism. The Tromso Study, J INTERN M, 247(3), 2000, pp. 325-330
Citations number
20
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Objective. To evaluate bone mineral density and blood pressure in asymptoma
tic hyperparathyroidism.
Design. A case-control study.
Setting. The participants obtained from an epidemiological survey in Tromso
1994-95, that included more than 27 000 subjects. The re-examination in 19
98 was performed at the University Hospital of Tromso, Norway.
Participants. Thirty-nine subjects with hyperparathyroidism and 72 control
subjects were studied.
Main outcome measures. Bone mineral density measurements of the lumbar spin
e and the proximal femur (femoral neck, Ward's triangle, and trochanter). S
ystolic and diastolic blood pressure.
Results. In the hyperparathyroidism group bone mineral density was signific
antly lower measured at the lumbar spine (1.000 +/- 0.181 vs. 1.079 +/- 0.1
94 g cm(-2), mean +/- SD, P < 0.01) and at the femoral neck (0.806 +/- 0.12
1 vs. 0.852 +/- 0.141 g cm(-2), P < 0.05). In the females, but not in the m
ales, blood pressure was significantly higher in the hyperparathyroidism gr
oup than in the control group [systolic blood pressure 146.7 +/- 18.6 vs. 1
37.4 +/- 23.0 mmHg (P < 0.05) and diastolic blood pressure 88.1 +/- 11.8 vs
. 82.2 +/- 10.6 mmHg (P < 0.05)]. In the females the number of subjects on
antihypertensive medication was significantly higher in the hyperparathyroi
dism group than in the control group (32.1% and 16.6%, respectively, P < 0.
01).
Conclusions. Subjects with asymptomatic hyperparathyroidism have moderately
reduced bone mineral density. In females with hyperparathyroidism there is
an increase in blood pressure.