Right temporal lobe glioblastoma presenting in the left orbit - Case report

Dissemination of gliomas outside the central nervous system without precedi ng neurosurgery is a rare phenomenon. Glial neoplasms presenting as bone le sions are even more rare. A case of glioblastoma multiforme (GBM) with init ial presentation in the orbit following a single generalized seizure is des cribed. Signs of intracranial hypertension resulted from subarachnoid tumor invasion. The patient was treated with whole-dose radiation therapy but su rvived for only 6 months following the initial presentation. An autopsy rev ealed a right temporal GBM with extensive subarachnoid spread and invasion in the left orbit and skull base. The literature on dissemination of primar y tumors of the brain is reviewed.