Ovarian stimulation in a woman with premature ovarian failure and X-autosome translocation - A case report

BACKGROUND: There are only a few reports on ovulation induction in women wi th premature ovarian failure resulting from an X chromosome abnormality. Up to now, there have been no publications on ovulation stimulation in a pati ent with an X-autosome translocation. CASE: A healthy, 29-year-old woman had premature ovarian failure (POF) but no other discernible pathologic clinical features. Laboratory tests prior t o initiating a stimulation cycle revealed a 46, XX t (X;16) karyotype. Gene tic counseling was proposed, and the risk of X chromosome abnormality was d iscussed. The couple decided to undergo ovulation induction. For treatment of infertility, clomiphene citrate had been administered in the past. Becau se those treatments were not successful, GnRH-a and follicle stimulating ho rmone treatment was recommended. The first treatment cycle was successful i n inducing ovulation, but on the 15th day after human chorionic gonadotropi n administration, menstruation occurred. The couple refused a second stimul ation, and menstruation occurred 32 days after the first. The patient then became amenorrheic again. CONCLUSION: At least some hope can be offered to infertile women with hyper gonadotropinism and X-autosomal translocation, although it is impossible to determine whether ovulation induction will result in pregnancy. New treatm ents can be anticipated for women with POF and X chromosome aberrations who have similar hormonal environments.