Objective: To compare the investigator-based Life Events and Difficulties S
chedule (LEDS) with a self-report measure (Life Events Checklist [LEC]) for
the purpose of measuring life stress in adolescents with and without a dia
gnosis of major depressive disorder (MDD). Method: Adolescents (aged 13-18
years) with a recent episode of MDD based on DSM-III-R (n=35) and normal co
ntrols free of any Axis I lifetime psychiatric disorder (n=35) were assesse
d using both the LEC and the LEDS. Results: Both measures predicted members
hip in the depressed and nondepressed groups of adolescents. Adolescents in
the depressed group were more likely to report a severe event on the LEDS
(97%) than adolescents in the nondepressed group (66%) (p=.001). Similarly,
subjects in the depressed group endorsed a greater number of negative even
ts (mean = 8.1) on the LEC than subjects in the nondepressed group (mean =
3.0) (p=.0001). An examination of potential provoking agents for episodes o
f major depression revealed that the LEC captured only 32% of preonset seve
re events and 36% of preonset major difficulties identified by the LEDS. Co
nclusions: Interpreted in light of relative advantages and disadvantages, t
he results suggest that checklist and interview measures each have distinct
advantages depending on the purpose for which they are being used.