Synthesis and characterization of peptidyl-cyclodextrins dedicated to drugtargeting

We have synthesized and investigated 8 peptidyl-cyclodextrin adducts in ord er to validate the general concept of drug-targeting. The adducts are compo sed of a beta- or gamma-cyclodextrin part and a peptidic moiety consisting of the neuropeptide Substance P or one of its shorter derivatives, Substanc e P4-11. All these new compounds were fully characterized by dedicated NMR experiments and by mass spectrometry. The inclusion properties of the cyclo dextrin moiety were also preserved as demonstrated by NMR experiments. Anti bodies raised against beta-, gamma-cyclodextrin and Substance P, respective ly, recognized the corresponding moiety in all prepared peptidyl-cyclodextr in derivatives.